1− 3 While antibiotic resistance can arise genetically from mutations and horizontal gene transfer, 4 bacteria in an isogenic population are known to display varying susceptibility to antibiotics. The growing bacterial resistance against our finite repertoire of antibiotics is an urgent global health problem. These results suggest a promising paradigm to renovate traditional antibiotics. aureus persisters 4–6 logs better than tobramycin, but remains noncytotoxic to eukaryotes. The resulting molecule spontaneously permeates membranes, retains the high antibiotic activity of aminoglycosides, kills E. By giving tobramycin the ability to induce nanoscopic negative Gaussian membrane curvature via addition of 12 amino acids, we transform tobramycin itself into a transporter sequence. We re-engineer antibiotics specifically for persisters using tobramycin, an aminoglycoside antibiotic that targets bacterial ribosomes but is ineffective against persisters with low metabolic and cellular transport activity. These persisters act as a genetic reservoir for resistant mutants and constitute a root cause of antibiotic resistance, a worldwide problem in human health. Most antibiotics target growth processes and are ineffective against persister bacterial cells, which tolerate antibiotics due to their reduced metabolic activity.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |